Kratom is available as leaves, powdered leaves, or gum. It can be smoked, brewed into tea, or mixed with liquid and ingested. Effects are dose-dependent; lower doses tend to produce a stimulant effect and higher doses produce an opioid effect.
A typical dose is 1 to 8 g. Airway management and naloxone treatment may be needed on an emergent basis if a user develops respiratory depression. Methoxetamine is a ketamine analog originally developed as an alternative to ketamine. Doses range from 20 to mg orally and 10 to 50 mg when injected. Effects may not be apparent for 30 to 90 minutes after the drug is snorted, which may cause users to take another dose or ingest a different substance, possibly leading to synergistic adverse effects.
Effects may emerge within 5 minutes when injected. The duration of effect generally is 5 to 7 hours—notably longer than ketamine—but as little as 1 hour when injected.
Anecdotal reports from people who use MXE indicate that tolerance builds up quickly and that the drug has a high potential for addiction. Some people report taking high doses several times a day in an effort to maintain the positive effects on their initial low doses.
This is often coupled with emotional difficulties and associated social problems. There is limited data regarding MXE dependence, but researchers believe that its similarity to ketamine may mean that it carries a similar risk of dependency. The length of time MXE stays in your system depends on several factors, including how much you take and how you take it i.
MXE is not detected via a standard urine toxicology screen. Addiction to MXE is certainly possible, especially since it is thought to affect the neurotransmitter dopamine, which signals the brain that a reward is on its way. When people experience a spike in dopamine levels, it reinforces the desire to use again and the brain requires more and more of the drug to achieve feelings of pleasure. The result: compulsive drug-seeking behavior.
This can include spending large amounts of time seeking and using the drug and neglecting work and family responsibilities. As there is very little information available, many addiction counselors and medical staff may not have even heard of the drug, let alone know about the effects.
This may make forming a therapeutic relationship and effective addiction treatment for this drug particularly challenging. Once people have developed a dependence on or addiction to MXE, they are likely to experience symptoms of withdrawal if they suddenly stop taking the drug. These symptoms can range from mild to serious and can impact the body and mind, including:. While there is no specific treatment for MXE addiction, there are some proven treatment options that could help you or someone you love.
Treatment may include supervised detox, rehab inpatient, outpatient, or residential , cognitive-behavioral therapy, family therapy, support groups, relapse prevention, and medication for any co-occurring mental illnesses. If you have a problem with MXE use, talk to your doctor. Together, you can figure out the right treatment to begin the road to lasting recovery. Don't wait to get help. The Substance Abuse and Mental Health Services Administration has a national helpline as well as an online treatment locator to find mental health services in your area.
Learn the best ways to manage stress and negativity in your life. Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine.
Hum Psychopharmacol. Ketamine-like effects after recreational use of methoxetamine. Ann Emerg Med. Here today, gone tomorrow…and back again? A review of herbal marijuana alternatives K2, Spice , synthetic cathinones bath salts , kratom, Salvia divinorum, methoxetamine, and piperazines. J Med Toxicol. Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine. Eur J Clin Pharmacol. Your Privacy Rights.
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I Accept Show Purposes. Table of Contents View All. These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken. They would not exist without him. Factsheet data is now cached locally - if you have visited a page you can now view it offline! Are you a harm reduction organisation using TripSit?
Let us know about you! Summary A popular dissociative drug which is an analogue of ketamine, though less sedating and more potent by weight, with a subjectively more 'complicated' set of effects. Dissociative Dissociatives are mostly NMDA receptor antagonists, these substances are hallucinogenic but different than psychedelics. Read more on TripSit Wiki
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